Bills vs. Eagles: NFL Week 16 Matchup Preview and Betting Odds
The Buffalo Bills, with an 11-4 record, are on a four-game winning streak as they prepare to face the Philadelphia Eagles, who have a 10-5 record, at Highmark Stadium on December 28, 2025. The Bills are favored by 1.5 points in what is expected to be a close game, with the over/under set at 44 points. In their previous game, the Eagles defeated the Washington Commanders 29-18, with Jalen Hurts throwing for 185 yards, two touchdowns, and no interceptions. The Bills also secured a victory in their last game, beating the Cleveland Browns 23-20. The latest NFL odds are provided by BetMGM Sportsbook, with updates available on Saturday at 4:55 p.m. ET. Remember to gamble responsibly and only use funds that you can afford to lose. If you or someone you know has a gambling problem, help is available through the National Council on Problem Gambling.