NFL Matchup Preview: Detroit Lions vs. Pittsburgh Steelers - December 21, 2025

The Detroit Lions will face off against the Pittsburgh Steelers at Ford Field on December 21, 2025. The Lions are favored to win by 6.5 points, with an over/under of 52 points set for the game. The Steelers recently defeated the Miami Dolphins with a score of 28-15, led by quarterback Aaron Rodgers who had an impressive performance. On the other hand, the Lions suffered a loss to the Los Angeles Rams in their previous game. The NFL odds for this matchup are provided by BetMGM Sportsbook, with updates available on the USA TODAY Sports Betting Scores Odds Hub. Gambling carries risks, and it is important to only wager money that you can afford to lose. While efforts are made to provide accurate information, mistakes can occur, and no guarantees are made regarding results or financial gain. Past performances do not guarantee future success, and betting odds can change rapidly. The content on this site aims to inform, entertain, and educate readers, and does not serve as professional advice. Gannett may earn revenue from sports betting operators for audience referrals, but this does not influence news coverage. If you or someone you know has a gambling problem, assistance is available through the National Council on Problem Gambling. Legal age restrictions apply for gambling, and it is essential to comply with local laws regarding sports betting and gambling.